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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: Cell Death Differ. 2010 May 14;17(11):1684–1696. doi: 10.1038/cdd.2010.48

Figure 8.

Figure 8

NO/cGMP protect from H2O2-induced apoptosis through inhibition of Drp1. Myogenic precursor cells were transfected with pcDNA3-Drp1-myc or pcDNA3-Drp1 K38A-myc and differentiated for 6 h. The cells were then exposed to H2O2 or vehicle in the presence or absence of l-NAME or ODQ. (a) Phosphatidylserine exposure to the plasma membrane in 7AAD-excluding cells. (b) The number of trypan blue-excluding cells. The panels show values±S.E.M. (n = 4). The asterisks and the crosses show significant differences (P<0.001) from the control of l-NAME or ODQ-treated cells expressing pcDNA-myc, and of the pCDNA3-Drp1 K38A-expressing cells from the cells expressing the empty vector, respectively