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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: Tetrahedron. 2006 Apr 17;62(16):3815–3822. doi: 10.1016/j.tet.2005.11.088

Table 1.

Synthesis of ynamides by alkynylation of carbamates

graphic file with name nihms-214844-t0001.jpg

Entry Carbamate Halo alkyne Ynamide Yield (%)a
1 1 R1=CH3 3 X=Br, R2=Hex graphic file with name nihms-214844-t0002.jpg 61
2 1 R1=CH3 4 X=I, R2=SiMe3 graphic file with name nihms-214844-t0003.jpg 64
3 2 R1=(CH2)2CH=CH2 5 X=Br, R2=C(CH3)=CH2 graphic file with name nihms-214844-t0004.jpg 68
a

Isolated yields of products purified by column chromatography.