Table 1.
Key pharmacologic characteristics
| TETRACYCLINE | DOXYCYCLINE | MINOCYCLINE | |
|---|---|---|---|
| GI absorption | 77–88% | 73–95% | 95–100% |
| Solubility | High | High | High |
| Permeability | Low | High | High |
| Volume of distribution | 108L | 50–80L | 80–115L |
| Protein binding | 55–64% | 82–93% | 76% |
| Lipophilicity | Low | Intermediate | High |
| Molecular weight | 444 | 462 | 457 |
| Dietary factors affecting absorption | Food, iron, calcium, magnesium, aluminum | Food (less affected than tetracycline), iron, calcium, magnesium, aluminum | Food (less affected than tetracycline or doxycycline), iron, calcium, magnesium |
| Availability in ER formulation | No | No | Yes |
- GI
gastrointestinal
- ER
extended release