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. 2011 Mar 8;9(3):e1001025. doi: 10.1371/journal.pbio.1001025

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Tg-induced activation of K_Ca channel in control HSG cells and cells expressing STIM1(⁶⁸⁴EE⁶⁸⁵) (note that these cells display I_CRAC when stimulated with Tg). Left panel shows development of the current at 0 mV and right panel shows the I–V relationship of the current. (B) Measurement of NFκB activation in HSG cells (control, +siOrai1, +SOAR, +shTRPC1). Conditions used for the experiments are shown in the figure and described in detail in Materials and Methods. (C) NFAT activation in HSG cells (control, +siOrai, or +shTRPC1).