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. Author manuscript; available in PMC: 2011 Apr 28.
Published in final edited form as: J Am Chem Soc. 2010 Apr 28;132(16):5711–5724. doi: 10.1021/ja9082182

Figure 8.

Figure 8

Apparent ligand dissociation constants as a function of pH. (A) pKD versus pH for anionic ligands: ●, azide; ■, KSCN; ▼, NaNO2; △, fluoride. Data for azide, KSCN, and NaNO2 binding were fit to eq 5 in the text, yielding pKa values of 8.7 ± 0.8, 8.5 ± 0.7, and 8.5 ± 0.9 respectively. (B) pKD versus pH for neutral ligands: ●, imidazole; ■, pyridine. Each plot was fit to eq 7 in the text, giving pKa values of 6.3 ± 0.6 and 9 ± 1 for imidazole and 5.1 ± 0.5 and 9.0 ± 0.5 for pyridine. (C) pKD versus pH for KCN. The data were fit to eq 6, yielding pKa values of 6.0 ± 0.7 and 8.8 ± 0.7.