Figure 1.

ET-1 regulates local and global Ca²⁺ signals in arterial myocytes. A, Confocal images illustrating average fluo-4 fluorescence in myocytes in the same artery in control and ET-1 (10 nmol/L). White boxes illustrate locations where sparks occurred during 10 seconds of imaging. Colored boxes illustrate locations from where normalized fluorescence (F/F₀) over time traces shown in C were determined. B, Two representative Ca²⁺ sparks that occurred at locations labeled in A for each condition. C, F/F₀ over time traces illustrate ET-1-induced Ca²⁺ wave activation. D, Mean data (n=7 for each condition). P<0.05: * vs control; # vs ET-1.