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. Author manuscript; available in PMC: 2011 Sep 3.
Published in final edited form as: Circ Res. 2010 Jul 8;107(5):631–641. doi: 10.1161/CIRCRESAHA.110.224345

Figure 3.

Figure 3

ET-1-induced IP3R-mediated SR Ca2+ release depolarizes mitochondria in arterial myocytes. A, ET-1 caused reproducible mitochondrial depolarization which was blocked by XeC (20 µmol/L). B, Concentration-dependent mitochondrial depolarization by ET-1 (n=4–7). C, Mean data for ET-1 (n=37), second ET-1 application (n=12), thapsigargin (100 nmol/L, n=18), ET-1+thapsigargin (n=18), XeC (20 µmol/L, n=12), ET-1+XeC (n=12), 60 mmol/L K+ (n=10), and CCCP (10 µmol/L, n= 65). ET-1 concentration was 30 nmol/L in all experiments. P<0.05: * vs control; # vs ET-1.