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. 2011 Feb 23;11:41. doi: 10.1186/1471-2180-11-41

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Copyright ©2011 Pasricha et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparative analysis of the frequency of SNPs in the mce operons genes of drug resistant (DR) and drug sensitive (DS) clinical isolates. SNPs were explored using Sequenom MassARRAY platform. DR (n = 59) and DS (n = 22) clinical isolates of M. tuberculosis were taken up for this study. The comparison between the two categories revealed that (A) mce1 and (B) mce4 operon genes were significantly more polymorphic in DS clinical isolates than DR isolates (*, p < 0.05) and (**, p < 0.01) respectively.