Table 1.
Polymorphisms in the genes of mce1 operon.
| mce1 operon | ||||||||
|---|---|---|---|---|---|---|---|---|
|
Gene Name (Accession Number) |
Nucleotide Change [GenBank Accession Number] |
Amino Acid Change |
Frequency Distribution of polymorphism (%) |
|||||
| Non Synonymous | Synonymous |
All isolates n = 112 |
DS n = 22 |
DR n = 59 |
SDR n = 15 |
MDR TB n = 19 |
||
|
yrbE1A [Rv0167] |
C14T [GenBank:HQ901088] |
Thr5Ile | NONE | (25.96) | (29.16) | (29.09) | (41.76) | (15.78) |
|
yrbE1B [Rv0168] |
T154G [GenBank:HQ901089] |
Tyr52Asp | NONE | (0.9) | NONE | (1.72) | NONE | (5.26) |
|
mce1A [Rv0169] |
C1075T C1323T [GenBank:HQ901082] |
Pr0359Ser | Tyr441Tyr | (1.87) | (4) | NONE | NONE | NONE |
|
mce1B [Rv0170] |
T536C [GenBank:HQ901085] |
Ile179Thr | NONE | (0.9) | (3.8) | NONE | NONE | NONE |
|
mce1C [Rv0171] |
G636C [GenBank: HQ901086] |
Glu212Asp | NONE | (0.9) | (3.8) | NONE | NONE | NONE |
|
mce1D [Rv0172] |
NONE | NONE | NONE | NONE | NONE | NONE | NONE | NONE |
|
lprK [Rv0173] |
NONE | NONE | NONE | NONE | NONE | NONE | NONE | NONE |
|
mce1F [Rv0174] |
G129T [GenBank: HQ901083] |
Lys43Asn | NONE | (0.9) | (4) | NONE | NONE | NONE |
Frequency of single nucleotide polymorphisms detected in the genes of mce1 operon. The nucleotide changes and the corresponding changes in amino acids are shown here. The frequency of SNPs was calculated from 112 clinical isolates. The data has been subdivided according to the drug susceptibility profile.
The single letter nucleotide designations used are as follows: A, adenine; C, cytosine; G, guanine and T, thymidine. The three letter amino acid designations used are as follows: Thr, threonine; Ile, isoleucine; Tyr, tyrosine; Asp, aspartic acid; Pro, proline; Ser, serine; Glu, glutamic acid; Lys, lysine and Asn, asparagine.
DS: drug sensitive, DR: drug resistant, SDR: single drug resistant, MDR TB: Multi drug resistant