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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: Nature. 2004 Nov 18;432(7015):332–337. doi: 10.1038/nature03096

Figure 1.

Figure 1

The stroma associated with normal mammary gland differs profoundly from stroma associated with a mammary carcinoma. (A) Note that the normal mammary gland has sparse connective tissue (arrow) surrounding the duct and abundant adipose tissue (*). (B) The carcinoma contains abundant connective likely as a result of growth factor production by the carcinogenic environment. Note the dense collagen bundles associated with fibroblasts (*) and the numerous small blood vessels and capillaries (arrow heads). The carcinoma cells form aberrant gland structures (green arrows) or grow in cords without gland formation (black arrow).