Table 1.
The fibroblast derived soluble factors regulate epithelial growth, differentiation and apoptosis32,71–73.
| Soluble factors | Cells Expressed | Responding cells | Possible role |
|---|---|---|---|
| HGF and MSP | Fibroblasts | Epithelia | + Proliferation |
| + Transformation | |||
| + Morphogenic | |||
| IGF-1, IGF-2 | Fibroblast | Epithelia (breast) | − Apoptosis |
| + Proliferation | |||
| EGF and TGF-α | Epithelia and fibroblasts | Epithelia | + Proliferation |
| + Morphogenic | |||
| TGF-β1, TGF-β2, TGF-β3 | Epithelia and fibroblasts | Epithelia and fibroblasts | − Proliferation |
| +/− Apoptosis | |||
| + Morphogenic | |||
| FGF7/KGF | Fibroblast | Epithelia | + Proliferation |
| + Morphogenic | |||
| IL6, LIF, and oncostatin M | Fibroblast | Epithelia (colonic) | + Proliferation |
| + Transformation | |||
| FGF2 | Fibroblast | Epithelia | + Proliferation |
| + Transformation | |||
| FGF10 | Fibroblast | Epithelia | + Proliferation |
| NGF | Fibroblast | Epithelia | + Transformation |
| Stromal cell-derived factor 1alpha(CXCL12) | Fibroblast | Epithelia (glioblastoma) | + Proliferation |
| + Transformation | |||
| Wnt1, Wnt3 | Fibroblast | Epithelia | + Proliferation |
| + Transformation | |||
| MMP-1, MMP-7 | Fibroblast | through ECM and growth factor activation in the stroma affect epithelia | +/− Proliferation |
| +/− Apoptosis | |||
| + Morphogenic | |||
The abbreviations are HGF, hepatocyte growth factor; MSP, macrophage stimulating factor; IGF, insulin growth factor; EGF, epidermal growth factor; TGF-β, transforming growth factor; FGF, fibroblast growth factor; KGF, keratinocyte growth factor; IL6, interleukin 6, LIF, leukemia inhibitory factor; NGF, nerve growth factor.