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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: Clin Exp Metastasis. 2008 Jun 6;25(6):601–610. doi: 10.1007/s10585-008-9183-1

Fig. 2.

Fig. 2

TGFβ1 and EGF promote ARCaP prostate cancer EMT as evidenced by morphology and gene expression analyses. (a) ARCaPE cells have a typical cobblestone-like epithelial morphology, which could be altered to mesenchymal-like morphology by simultaneous treatment of TGFβ1 and EGF for 3–37 days. (b) The treatment inhibited the epithelial E-cad marker, but increased the mesenchymal vimentin and RANKL markers. (c) Effect of TGFβ1 and EGF treatment was transient, as termination of the treatment led to re-expression of the E-cad with decreased vimentin expression, 9 days after removal of the growth factors