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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: Clin Exp Metastasis. 2008 Jun 6;25(6):601–610. doi: 10.1007/s10585-008-9183-1

Fig. 4.

Fig. 4

Stable β2-m expression in human breast (MCF7, a), lung (H358, b) and renal (SN12C, c) cancer cells increased the expression of RANKL protein and the signaling mediated by Stat3 (increased both basal level and pStat3), Snail and LIV1 (a gene drives EMT in Zebrafish). β2-m-1 and β2-m-2 represent, respectively, the intermediate and high β2-m stably expressing clones. Note that the levels of activation of cell signaling correlated with levels of β2-m expression. P: parental cells. Neo: neo-transfected cells. A represents western blots of RANKL and β-actin, B represents the RT-PCR data of stat3, LIV-1 and Snail with GAPDH as a control gene, and C represents the western blots of p-stat3, stat3 with β-actin as the loading control