Figure 1.

Summary of phage screening strategy. Libraries of targeted phage were added to either intact matrix (IT1), sonicated immobilized matrix (IT6, IT7 and IT9) or thin sections of matrix (IT8). The blocking strategies with phosphate buffer (P04), bovine serum albumin (BSA) or non fat milk (NFM) were deployed as indicated, and eluates from samples treated with chondroitin sulfate, high salt or high acid, which were processed over three to four rounds (R3, R3/4) of selection before sequence analyses, were used.