Table 1.
Schedule indicating the order of PfAMA1 antigen administration to rabbits.
| Immunization group | Antigens and immunization | *Number of rabbits | ||
|---|---|---|---|---|
| Day 0 | Day 28 | Day 56 | ||
| 1 (f3h) | FVO AMA1 | 3D7 AMA1 | HB3 AMA1 | 6 |
| 2 (hf3) | HB3 AMA1 | FVO AMA1 | 3D7 AMA1 | 6 |
| 3 (h3f) | HB3 AMA1 | 3D7 AMA1 | FVO AMA1 | 4 |
| 4 (NA mix) | NA mix | NA mix | NA mix | 6 |
| 5 (DiCo mix) | DiCo mix | DiCo mix | DiCo mix | 6 |
f (FVO), 3 (3D7) and h (HB3) in groups 1, 2 and 3 indicate the order of antigen administration.
NA mix - an equimolar mixture of AMA1 antigens from the FVO, HB3 and 3D7 strains of P. falciparum, administered at all three immunization time points.
DiCo mix - an equimolar mixture of the three Diversity-covering (DiCo) proteins, administered at all three immunization time points.