Table 3.
Valvular lesion characteristics in patients with systemic vasculitides.
| Reference | Valve lesion onset | Valve lesion | Mechanism of valvular disease | Valvular treatment | Outcome | Valve histology |
|---|---|---|---|---|---|---|
| Stöllberger [19] | After 3 days steroïds | AR | Vegetation | - | AVR | Non specific |
| Levine [15] | After 6 weeks of ENT signs no IST | MR | ? | - | Died of heart failure | - |
| Davenport [6] | At initial presentation | AR | Leaflet perforation and tissue disruption |
1 year IST | AVR | Non specific |
| At initial presentation | AR | Thickened leaflets | IST | Worse, awaiting AVR | - | |
| Grant [10] | After 1 year of CYC | AR | Dilation of ascending aorta | 20 Mo IST | AVR | Non specific |
| Goodfield [9] | At initial presentation | AR | Thickened leaflets and mass obstructing the left ventricular outflow tract | 6 weeks IST | Thickening & mass disappeared. AVR because of LV dilatation & shrunken Ao leaflet | Non specific |
| Bruno [4] | 3 years after illness onset, no IST | AR | Thickened, rigid and retracted leaflets | _ | AVR | Specific |
| Herbst [12] | At initial presentation | MR | Mass involving a leaflet | MVR & AVR | Specific | |
| Gerbracht [8] | After 5 days CYC | AR | Vegetation | IST | Complete resolution | - |
| Greidinger [11] | After 3 weeks CYC | AR | ? | IST | Lesion unchanged | - |
| MR | ? | IST | Lesion unchanged | - | ||
| Leff [14] | At initial presentation | AR | Perforation of 2 leaflets | 1 year IST | Ao valve repair: homograft | - |
| Yanda [20] | 1 year after initial presentation, no IST |
AR | Thickened leaflet | - | AVR | Non specific |
| MR | Thickened leaflet | IST | ? | - | ||
| Dabbagh [5] | After 3 weeks CYC | AR | ? | IST | ? | - |
| Fox [7] | At initial presentation | AR | Prolapsing Ao leaflets and discrete Ao leaflet deficiency | 5 Mo IST | AVR | Non specific |
| MR | ? | IST | ? | - | ||
| Anthony [2] | At initial presentation | AS | Vegetation | 3 Mo IST | Lesion unchanged | - |
| Paik [17] | At initial presentation | Ao vegetations | Vegetation | IST | ? | |
| Mishell [16] | At initial presentation | Ao and M vegetations | Vegetations | IST | Died | Non specific |
| Ramakrishnan [18] | At initial presentation | M masses | Multiple masses in atriums and on MP | Few days IST | Died | - |
| Attaran [3] | 30 years after illness onset, IST? | Ao and M mass, MR, MS | Mass involving an Ao and an M leaflet | IST | MVR & AVR | Non specific |
| Koyalakonda [13] | Not at initial presentation and under treatment | MS & MR AR |
M mass involving leaflet Thickened Ao valve |
IST IST |
Mass unchanged: MVR AR progressed: AVR |
Non specific |
| Present report | At initial presentation | AR | Septal thickening: incomplete closure of Ao valve, thickened leaflets | 4 Mo IST | AVR | Non specific |
?: Unknown; AR: aortic regurgitation; Ao: aortic; AS: aortic stenosis; AVR: aortic valve replacement; CYC: cyclophosphamide; IST: immunosuppressive therapy; LV: left ventricular; M: mitral; Mo: months; MP: mitral prothesis; MR: mitral regurgitation; MS: mitral stenosis; MVR: mitral valve replacement.