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Effect of various inhibitors on the [Ca2+]o or the [Gd3+]o-induced vasoconstriction. A. An increase in [Ca2+]o from 5 to 12.5 mM caused a vasoconstriction of the pulmonary arteries (P < 0.01 versus vehicle). In the 10 mM caffeine, 50 μM thapsigargin, 50 μM U73122 or 150 μM 2-APB pretreated groups, the vasoconstriction of the pulmonary arteryies was attenuated, but 50 μM U73343 had no effect on the vasoconstrictions (n = 8). B. [Gd3+]o from 10-6 to 10-2 M caused similar changes.
