Table 1.

Regimens and drug doses of control and experimental arms

Setting	Treatment Arm	Regimens	Dose	Schedule	Reference
Locally advanced	Control	Epirubicin	75 mg/m², d 1	Every 3 weeks for 4 cycles	de Matteis A, 2002
		Docetaxel	80 mg/m², d 1
	Experimental	Epirubicin	30 mg/m², dd 1-8-15	Every 4 weeks for 3 cycles	Wenzel C, 2002
		Docetaxel	35 mg/m², dd 1-8-15
Metastatic, no previous anthracyclines	Control	Epirubicin	60 mg/m², d 1	Every 3 weeks for 6 cycles	Trudeau ME, 1999
		Docetaxel	75 mg/m², d 1
	Experimental	Epirubicin	25 mg/m², dd 1-8-15	Every 4 weeks for 6 cycles	Wenzel C, 2002
		Docetaxel	30 mg/m², dd 1-8-15
Metastatic, previously treated with anthracyclines	Control	Capecitabine	1000 mg/m², b.i.d., dd 1-14	Every 3 weeks for 6 cycles	Pronk LC, 2000
		Docetaxel	75 mg/m², d 1
	Experimental	Capecitabine	625 mg/m², b.i.d., dd 5-18	Every 4 weeks for 6 cycles	Nadella P, 2002
		Docetaxel	35 mg/m², dd 1-8-15