Table 3.
EORTC quality of life scores by treatment arm
| Mean baseline score (SD) | Mean 6 weeks score (SD) | Mean difference (SD) | |||||
|---|---|---|---|---|---|---|---|
| 3-weekly | Weekly | 3-weekly | Weekly | 3-weekly | Weekly | P value* | |
| N = 48 | N = 41 | N = 48 | N = 41 | ||||
| Global QoL | 62.8 (22.8) | 64.0 (21.2) | 67.9 (16.0) | 60.0 (19.0) | 5.0 (26.0) | -3.5 (20.5) | 0.03 |
| Functional scales | |||||||
| Physical functioning | 86.3 (16.6) | 81.9 (19.6) | 82.3 (16.8) | 78.0 (18.0) | -4.0 (11.8) | -3.9 (14.3) | 0.64 |
| Role functioning | 84.7 (22.2) | 79.3 (26.0) | 84.0 (21.2) | 72.0 (23.4) | -0.7 (22.3) | -7.3 (24.7) | 0.02 |
| Emotional functioning | 59.2 (23.5) | 60.4 (22.2) | 71.5 (19.1) | 64.8 (24.4) | 12.3 (21.6) | 4.5 (18.5) | 0.055 |
| Cognitive functioning | 88.9 (14.7) | 89.8 (21.0) | 90.3 (14.9) | 83.7 (23.7) | 1.4 (19.1) | -6.1 (18.5) | 0.055 |
| Social functioning | 81.6 (21.5) | 80.5 (25.0) | 80.2 (26.6) | 69.5 (28.6) | -1.4 (32.8) | -11.0 (29.7) | 0.07 |
| Symptoms | |||||||
| Pain | 23.6 (27.9) | 26.0 (25.3) | 15.3 (19.1) | 22.4 (19.9) | -8.3 (23.8) | -3.7 (19.9) | 0.08 |
| Loss of appetite | 13.2 (23.6) | 13.8 (23.5) | 15.3 (21.7) | 14.6 (21.1) | 2.1 (29.5) | 0.8 (24.1) | 0.86 |
| Constipation | 13.9 (16.6) | 15.4 (24.8) | 17.7 (23.9) | 20.0 (28.0) | 4.3 (26.6) | 5.8 (31.9) | 0.71 |
| Financial | 18.8 (26.5) | 19.5 (30.7) | 15.3 (23.8) | 35.0 (33.3) | -3.5 (22.0) | 15.4 (37.3) | 0.0007 |
| Fatigue | 19.4 (19.7) | 24.1 (25.0) | 31.6 (19.0) | 36.9 (20.6) | 12.2 (16.0) | 12.7 (26.1) | 0.39 |
| Nausea/vomiting | 5.2 (12.0) | 7.3 (14.5) | 17.4 (25.0) | 19.5 (22.6) | 12.2 (24.0) | 12.2 (21.4) | 0.87 |
| Sleeping disturbance | 27.7 (28.9) | 40.0 (31.3) | 22.9 (26.8) | 29.2 (32.2) | -5.7 (28.1) | -10.8 (28.6) | 0.90 |
| Diarrhoea | 5.6 (14.3) | 2.6 (9.0) | 9.0 (17.9) | 12.2 (20.8) | 3.5 (19.7) | 9.4 (20.2) | 0.31 |
| Dyspnoea | 5.6 (12.6) | 14.6 (25.9) | 9.0 (16.5) | 19.2 (21.2) | 3.5 (15.7) | 4.2 (25.2) | 0.10 |
SD: standard deviation; * bold p-values are statistically significant