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. 2011 Feb 21;11:79. doi: 10.1186/1471-2407-11-79

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Copyright ©2011 Valentine et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nutlin-3 induces p53-independent cell cycle checkpoint controls. HCT116^p53+/+and HCT116^p53-/-cells were treated with either 0, 10, 15 or 20 μM Nutlin-3 (Nut) or 100 μM of Etoposide (Eto). After 18 hours, cell cycle distribution was assessed using flow cytometry. (A) Chart showing percentage of HCT116^p53+/+cells in either G1 or G2 cell cycle population following either Nutlin-3 or etoposide treatment as described above. (B) Chart showing percentage of HCT116^p53-/-cells in both G1 and G2 cell cycle population following either Nutlin-3 or Etoposide treatment as described above.