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Modulation of Akt (pThr308) and ERK1/2 (pThr185/Ptyr187) phosphorylation by axitinib, SN-38, and their combination in HMVEC-d (A), Capan-1 (B), and MIAPaCa-2 (C) cells after 72 hours of treatment. pAkt and pERK1/2 concentrations were measured by ELISA kits, and they were normalized to total Akt and ERK1/2 protein concentration, respectively. Columns and bars indicate mean values ± SE, respectively. *P < .05 versus vehicle-treated controls.
