Figure 7.

In vivo antitumor effects of the single drugs (irinotecan 100 mg/kg i.p. every week and axitinib 25 mg/kg p.o. twice/daily) and simultaneous combination of irinotecan and axitinib schedules on Capan-1 tumors xenotransplanted in CD nu/nu mice expressed as percent T /C value. Columns indicate percent T/C values. *P < .05 axitinib alone and axitinib + irinotecan versus irinotecan alone; ^#P < .05 axitinib + irinotecan versus axitinib alone. A indicates axitinib; A + I, axitinib + irinotecan; I, irinotecan.