. 2011 Mar 8;6(3):e17426. doi: 10.1371/journal.pone.0017426

Table 1. Human FEZ2-interacting proteins identified by the yeast two-hybrid system screen.

Gene	Acession no.	Protein Description¹	Coded protein residues (complete)	Coded protein residues (retrieved)²	UNC76³	FEZ1³	FEZ2³	Biological Process (GO)⁴
AATF	NP_036270	apoptosis antagonizing transcription factor	560	11–319	+	+	+	apoptosis
ATP6V1H	NP_057078	H(+)-transporting two-sector ATPase	247	63–234	+	+	+	ion transport
C1orf216	NP_689587	hypothetical protein LOC127703	229	20–229	+	+	+	UNKNOWN
C10orf54	Q9H7M9	Platelet receptor Gi24 precursor	311	215–311			+	UNKNOWN
C10orf78	NP_001002759	hypothetical protein LOC119392 isoform a	245	6–245	+	+	+	UNKNOWN
C12orf51	NP_001103132	AF-1 specific protein phosphatase	3996	2878–3161		+	+	protein modification
C14orf94	CAD62584	HAUS augmin-like complex, subunit 4	387	16–333	+	+	+	centrosome organization
CAP1	EAX07240	CAP, adenylate cyclase-associated protein 1 (yeast)	468	163–468	+	+	+	cytoskeleton/cell polarity/signal transduction
CDKN1	EAW96276	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	53	1–53	+	+	+	apoptosis/cell growth
CHERP	BAD92967	calcium homeostasis endoplasmic reticulum protein	399	301–399		+	+	nervous development
DEFA3	AAA35753	neutrophil peptide 3 precursor	65	50–65	+	+	+	xenobiotic metabolism
DNAJB11	NP_057390	DnaJ (Hsp40) homolog, subfamily B, member 11 precursor	358	277–358			+	protein folding
DNML1	EAW88521	dynamin 1-like, isoform CRA_c	789	549–789	+	+	+	endocytosis
DRAP1	NP_006433	DR1-associated protein 1	205	1–133	+	+	+	transcription
DRG2	BAD92577	developmentally regulated GTP binding protein 2 variant	259	51–259	+	+	+	signal transduction
EEF1G	AAH21974	H sapiens eukaryotic translation elongation factor 1 gamma	355	19–346			+	translation
EI2B5	EAW78300	eukaryotic translation initiation factor 2B, subunit 5 epsilon	442	327–434	+	+	+	translation/hormone mediated signaling
FEZ1	EAW67636	fasciculation and elongation protein zeta 1 (zygin I)	392	131–371	+	+	+	nervous development
FEZ1	NP_072043	zygin 1 isoform 2	104	1–89			+	nervous development
GNAS	AAH89157	GNAS complex locus	380	293–380			+	signal transduction
GOLPH3L	EAW53527	golgi phosphoprotein 3-like	299	159–299	+	+	+	UNKNOWN
GPRASP2	NP_612446	G protein-coupled receptor associated sorting protein 2	838	496–812	+	+	+	UNKNOWN
GTF2IRD2	AAQ19673	general transcription factor II i repeat domain 2	949	565–603			+	transcription
GTPB6	NP_036359	pseudoautosomal GTP-binding protein-like protein	403	98–347			+	UNKNOWN
HSP90B1	EAW97723	heat shock protein 90 kDa beta (Grp94), member 1	367	1–287			+	apoptosis/protein folding/muscular contraction
HSPA1A	BAD93055	heat shock 70 kDa protein 1A variant	709	75–163			+	response to stress
IGL@	AAH71804	IGL@ protein	236	1–236			+	UNKNOWN
IK	EAW62028	IK cytokine, down-regulator of HLA II	557	119–333	+	+	+	cell-cell signaling
INPP1	NP_002185	inositol polyphosphate-1-phosphatase	399	355–399		+	+	signal transduction
INTS8	NP_060334	integrator complex subunit 8	995	508–816	+	+	+	snRNA proccessing
MCM7	NP_877577	minichromosome maintenance complex component 7	543	410–543	+	+	+	transcription/cell cycle
MED7	NP_004261	mediator complex subunit 7	233	116–233	+	+	+	transcription
MLF1IP	NP_078905	MLF1 interacting protein	418	243–263	+	+	+	transcription
NFS1	BAD96959	NFS1 nitrogen fixation 1 isoform a precursor variant	457	417–457			+	metabolic proccess
NQO2	CAI23293	NAD(P)H dehydrogenase, quinone 2	172	1–115			+	oxidation reduction
OS9	NP_006803	amplified in osteosarcoma isoform 1 precursor	667	389–635		+	+	endoplasmatic reticum stress
PDCD7	AAI31705	PDCD7 protein	270	57–270	+	+	+	apoptosis
PTN	EAW83871	Pleiotrophin	246	105–223	+	+	+	nervous development
RARA	EAW60657	retinoic acid receptor, alpha, isoform CRA_e	520	111–327	+	+	+	transcription
RPL27	EAW60910	ribosomal protein L27, isoform CRA_b	80	53–80	+	+	+	translation
RPL38	NP_000990	RPL38 ribosomal protein L38	70	1–70			+	translation
RPS25	NP_001019	ribosomal protein S25	125	1–114			+	translation
SAP30	NP_003855	Sin3A-associated protein, 30 kDa	220	1–220	+	+	+	transcription
SAP30L	NP_078908	SAP30-like	183	1–183	+	+	+	transcription
SCOC	EAX05102	short coiled-coil protein, isoform CRA_a	122	42–122	+	+	+	UNKNOWN
SERPINF1	P36955	Pigment epithelium-derived factor precursor (PEDF)	418	16–267			+	nervous development
SFRS8	EAW98526	splicing factor, arginine/serine-rich 8	951	263–511	+	+	+	transcription
SHMT1	BAD97272	serine hydroxymethyltransferase 1 (soluble) isoform 1 variant	483	364–483			+	hormone mediated signaling
SLC25A37	AAF71063	PRO1584	81	1–58	+	+	+	muscular constraction
SLTM	EAW77552	SAFB-like, transcription modulator	1168	389–723		+	+	transcription/apoptosis
SMC3	BAF98736	structural maintenance of chromosomes 3	1217	766–1059	+	+	+	sister chromatides cohesion/signal transduction
STRA13	NP_659435	stimulated by retinoic acid 13	63	3–63	+	+	+	UNKNOWN
TBC1D25	NP_002527	TBC1 domain family, member 25	688	498–677	+	+	+	regulation Rab GTPase activity
TLOC1	Q99442	Translocation protein SEC62	399	2–95			+	cotranslational protein targeting to membrane
TNNC2	NP_003270	fast skeletal muscle troponin C	160	1–137			+	muscular constraction
TSNAX	NP_005990	translin-associated factor X	290	1–276	+	+	+	cell differentiation
TUBA1B	BAF82043	tubulin, alpha 1b	451	285–432			+	cytoskeleton
WWC1	EAW61508	WW, C2 and coiled-coil domain containing 1	1018	775–1018	+	+	+	UNKNOWN
“SIH”	A61065	sucrase-isomaltase homolog – human	48	1–44	+	+	+	UNKNOWN

Results obtained from BLASTX (GenBank);

It is depicted the mininum length of the retrieved sequences which could be visualized by forward DNA sequencing only,

Interaction confirmed (+) by yeast two hybrid system with UNC-76, FEZ1 or FEZ2 proteins;

⁴

Biological process based on the GO database (other functions may be known).