Table 4. Antibody and cytokine mean, standard deviation and median in patients with different types of nerve function impairment.
| Patient Details | |||||||||
| No NFI(n = 136) | Sensory NFI | Motor NFI | |||||||
| No sensory NFI(n = 149) | New sensory NFI(n = 50) | Old sensory NFI (n = 104) | Only new +/− old sensory NFI (n = 31) (no motor NFI) | No motor NFI (n = 244) | New motor NFI (n = 33) | Old motor NFI (n = 26) | Only new +/− old motor NFI (n = 13) (No sensory NFI) | ||
| PGL – IgG (AU) | 79.9±87.959.0 | 85.3±113.459.0 | 84.7±53.574.0 | 122.1±159.173.5 | 85.5±49.975.0 | 97.0±117.169.0 | 109.8±165.466.0 | 88.6±141.956.0 | 141.8±260.143.0 |
| PGL – IgM (AU) | 110.8±18963.5 | 142.3±349.263.0 | 116.1±126.673.0 | 188.2±351.972.0 | 125.8±127.490.0 | 144.2±254.272.0 | 241.0±636.462.0 | 129.8±330.961.5 | 471.9±986.255.0 |
| LAM – IgG1 (AU) | 8.03±18.90.0 | 7.7±18.20.0 | 12.6±18.83.5 | 15.1±25.44.0 | 10.6±17.71.0 | 11.2±21.81.0 | 11.5±17.35.0 | 9.1±20.50.5 | 4.4±5.02.0 |
| LAM – IgG3 (AU) | 9.4±21.74 .0 | 8.9±20.84.0 | 11.2±12.86.0 | 9.8±11.46.0 | 11.5±14.86.0 | 9.9±18.15.0 | 8.2±8.45.0 | 8.2±12.54.0 | 4.4±3.33.0 |
| S-100 Antibody (AU) | 59.2±43.349.0 | 58.8±42.949.0 | 52.9±35.445.0 | 70.9±52.758.0 | 55.1±39.544.0 | 61.4±46.449.0 | 55.2±34.959.0 | 75.0±50.359.0 | 54.9±39.139.0 |
| Anticeramide Antibody (OD) | 0.7±0.40.6 | 0.7±0.50.6 | 0.6±0.30.6 | 0.8±0.50.6 | 0.7±0.40.6 | 0.7±0.50.6 | 0.7±0.50.6 | 0.6±0.60.5 | 0.8±0.70.6 |
| TNF alpha (concentration) | 39.7±103.12.3 | 40.1±103.02.3 | 103.5±238.32.8 | 35.4±100.22.3 | 91.1±217.32.2 | 44.9±124.32.3 | 96.5±218.23.2 | 27.0±89.11.0 | 44.3±105.41.5 |
Notes:
AU – Arbitrary Units, OD – Optical Density.
Kruskal-Wallis non-parametric testing used for all significance testing.
Baseline serum was available from all 303 cases in the study. Antticeramide was not assessed for 7 individuals.
For PGL1_IgG, No Sensory NFI versus Old NFI p<0.05, (No Sensory NFI versus Old Sensory NFI p = 0.076).
For PGL1_IgM, (No Motor NFI versus Old Motor NFI p = 0.0926).
For LAM_IgG1, No Sensory NFI versus Old NFI p<0.01, No Sensory NFI versus New Sensory NFI p<0.05.
For LAM_IgG3, No Sensory NFI versus Old NFI p<0.01, No Sensory NFI versus New Sensory NFI p<0.01.
For S100, No Sensory NFI versus Old NFI p<0.05, Old Sensory NFI versus New Sensory NFI p<0.01. (No Motor NFI versus Old Motor NFI p = 0.0932).