Table 3.
Genetic Model |
Behavioral Phenotype | Circuit Phenotype | Rescue (of overgrooming behavior) |
Refs |
---|---|---|---|---|
Slitrk5−/− | ObF cortical activity | [28] | ||
Repetitive grooming (head) | ||||
Striatal volume | Fluoxetine (21 days) | |||
Anxiety-like behaviors | ||||
Corticostriatal transmission | ||||
Sapap3−/− | Fluoxetine (6 days) | [82] | ||
Repetitive grooming (head) | Corticostriatal transmission | |||
Anxiety-like behaviors | Genetic (overexpression of Sapap3 in ST) |
|||
Hoxb8−/− | Repetitive grooming (body) | Bone marrow transplant | [91] | |
Repetitive grooming (cagemates) |
Subcutaneous lidocaine (acute) |
[90] |
Abbreviations: ObF, Orbitofrontal cortex; ST, striatum.