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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Trends Neurosci. 2011 Mar;34(3):143–153. doi: 10.1016/j.tins.2011.01.001

Table 3.

Summary of the Slitrk5, SAPAP3 and Hoxb8 genetic mouse models for OCD

Genetic
Model		 Behavioral Phenotype Circuit Phenotype Rescue
(of overgrooming
behavior)		 Refs
Slitrk5−/− Inline graphic ObF cortical activity [28]
Inline graphic Repetitive grooming (head)
Inline graphic Striatal volume Fluoxetine (21 days)
Inline graphic Anxiety-like behaviors
Inline graphic Corticostriatal transmission
Sapap3−/− Fluoxetine (6 days) [82]
Inline graphic Repetitive grooming (head) Inline graphic Corticostriatal transmission
Inline graphic Anxiety-like behaviors Genetic (overexpression
of Sapap3 in ST)
Hoxb8−/− Inline graphic Repetitive grooming (body) Bone marrow transplant [91]
Inline graphic Repetitive grooming
(cagemates)		 Subcutaneous lidocaine
(acute)		 [90]

Abbreviations: ObF, Orbitofrontal cortex; ST, striatum.