Table 2.

Averaged interaction energies for the specific interactions observed in the NRP1 – RPAR complex. The energies, which were averaged over the whole trajectories, were calculated considering the non-bonding contributions: van de Waals and electrostatics. The first amino acid refers to NRP-1 and the second refers to RPAR. C-Arg corresponds to the C-terminal Arg in RPAR. Interaction energies were evaluated considering all the atoms in the participating amino acids and not just the interacting centers.

Interaction in NRP1 – RPAR	Average energy (kcal·mol−1)
Ser 346 – C-Arg	−25.2±0.6
Thr349 – C-Arg	−23.4±0.7
Asp320 – C-Arg	−78.7±0.9
Tyr297 – Pro2	−6.0±0.2