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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Br J Dermatol. 2011 Apr;164(4):750–758. doi: 10.1111/j.1365-2133.2010.10129.x

Figure 6. Systemic administration of antibodies targeting murine TNFα leads to significant improvement in the psoriasiform skin phenotype in KC-Tie2 mice.

Figure 6

Average epidermal thickness measures performed on H&E stained sections (a) following 4 weeks of treatment with either TNFα antibodies or IgG control demonstrates increased acanthosis in KC-Tie2 + IgG skin compared to control skin treated with either IgG or TNFα antibodies. Epidermal thickness in KC-Tie2 mice treated with TNFα antibodies is significantly decreased compared to KC-Tie2 + IgG animals, but remains thicker than control animals. TNFα antibody treatment results in a return of T cell and APC numbers back to control mouse levels. * p≤0.05 compared to control + IgG; ** p≤0.05 compared to KC-Tie2 + IgG.