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Tachybradycardia produced by prolonged isoproterenol and ZD 7288 infusion. The figure shows pseudo ECG from canine isolated RA. Upper panel, eight episodes of tachybradycardia. Lower panel, expanded view of a section marked by asterisk (*) showing 4.0 s and 3.5 s pauses. This figure was reproduced with permission from Joung, et al.39 RA, right atrium.
