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. 2011 Jan 29;52(2):263–267. doi: 10.3349/ymj.2011.52.2.263

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© Copyright: Yonsei University College of Medicine 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — High power electron microscopic findings (9.0 × 9,000). (A) Wild type: the arrow shows large amounts of glycogen particles in the cytoplasm. (B) MPS II model: the arrow shows accumulation of GAG in lysosomes and scanty glycogen content in the cytoplasm. (C) Low dose ERT group: GAG in the lysosomes decreases but restoration of glycogen in the cytoplasm is not remarkable. (D) High dose ERT group: GAG in the lysosomes nearly disappears and glycogen particles in the cytoplasm are restored. MPS II, mucopolysaccharidosis II; GAG, glycosaminoglycan; ERT, enzyme replacement therapy.