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. 2011 Jan 25;23(1):350–363. doi: 10.1105/tpc.110.080150

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© 2011 American Society of Plant Biologists

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Figure 8. — Model of ATX1 Interactions at Two Locations in Target Genes.

A representation of an ATX1-dependent gene with its promoter (thick dark arrow) in a nucleosome-free region, and with the remainder of the gene complexed with nucleosomes (striped orange circles) containing H3K4me2 marks (me2), which are assumed to be the substrate for the trimethylating activity of ATX1 in this model, is shown.

(A) TBP, ATX1, and Pol II participate in the formation of a protein complex at the promoter, wherein the interaction of ATX1 with the nonphosphorylated form of the CTD of Pol II and additional undefined ATX1 interactions help stabilize this complex.

(B) Transcription elongation has moved Pol II to the +300-bp region of the transcribed gene, and Ser5 has become phosphorylated (red S in CTD consensus repeat YSPTSPS), recruiting ATX1 and facilitating trimethylation of H3K4 (me3) in this region.

(C) Continued transcription elongation by Pol II changes the phosphorylation status of the CTD to Ser2P (red S in CTD consensus repeat YSPTSPS). ATX1 has been released from Pol II as it does not bind to the Ser2P form of CTD.