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. Author manuscript; available in PMC: 2011 Mar 9.
Published in final edited form as: Nature. 2010 Sep 9;467(7312):214–217. doi: 10.1038/nature09337

Figure 1.

Figure 1

Productive infection of MDDC with HIV-1 induces a type I interferon response. (a) GFP expression and CD86 surface expression in monocyte-derived dendritic cells (MDDC) at 48h after infection with HIVGFP(G) and SIVVLP(G), alone or in combination. (b) Immunoblot of phospho-STAT1 and total actin expression over time in MDDC infected with HIVGFP(G) and SIVVLP(G) or treated with LPS. (c) Type I interferon activity in the supernatant of MDDC or activated CD4+ T cells infected with SIVVLP(G) alone or in combination with dilutions of HIVGFP(G) or with Sendai virus (SeV). (d) Type I interferon activity in supernatants of MDDC, 293FT and THP-1 cells infected with SIVVLP(G) alone or in combination with dilutions of HIVGFP(G) or transfected with poly(I:C) or RNA from Newcastle Disease Virus (NDV)-infected cells.