Table III.
ORs and 95% CIs for the association between dietary variables and advanced colorectal adenoma stratified by genotype. Limited to SNPs with statistically significant tests for interaction before correction.
| Dietary Intake | Gene | Locus | Genotype | Cases/Controls | ORa | Pinteractionb | Correctedc Pinteraction |
|---|---|---|---|---|---|---|---|
| PhIP per 1000 ng/day | CYP1B1 | rs10012 | CC | 344/375 | 0.81 (0.58–1.12) | 0.019 | 0.384 |
| CG | 293/296 | 1.47 (0.93–2.30) | |||||
| GG | 71/59 | 1.76 (0.60–5.21) | |||||
| CG/GG | 364/355 | 1.53 (1.02–2.30) | |||||
| CYP1B1 | rs1056836 | CC | 232/250 | 1.86 (1.07–3.22) | 0.019 | 0.384 | |
| CG | 337/344 | 0.86 (0.64–1.15) | |||||
| GG | 137/137 | 0.82 (0.33–2.08) | |||||
| CG/GG | 474/481 | 0.85 (0.64–1.13) | |||||
| NQO1 | rs1800566 | CC | 416/474 | 1.03 (0.76–1.40) | 0.007 | 0.340 | |
| CT | 244/225 | 0.99 (0.60–1.61) | |||||
| TT | 25/17 | - | |||||
| CT/TT | 269/242 | 0.80 (0.52–1.24) | |||||
| B[a]P per 100 ng/day | CYP1B1 | rs10012 | CC | 344/375 | 0.74 (0.55–1.00) | 0.005 | 0.340 |
| CG | 293/296 | 1.25 (0.94–1.68) | |||||
| GG | 71/59 | 1.66 (0.73–3.81) | |||||
| CG/GG | 364/355 | 1.29 (0.99–1.68) | |||||
| CYP3A4 | rs2242480 | GG | 558/579 | 1.02 (0.83–1.21) | 0.021 | 0.384 | |
| GA | 126/131 | 1.13 (0.69–1.85) | |||||
| AA | 12/14 | - | |||||
| GA/AA | 138/145 | 0.89 (0.56–1.42) | |||||
| Nitrate + Nitrite Per 0.5 mg/day | CYP1A1 | rs1048943 | AA | 646/684 | 1.03 (0.92–1.15) | 0.022 | 0.384 |
| AG | 44/38 | 1.11 (0.75–1.59) | |||||
| GG | 2/3 | - | |||||
| AG/GG | 46/41 | 1.14 (0.79–1.64) |
a
Adjusted for age, gender, and ethnicity.
b
Likelihood ratio test for model with cross-product terms of dietary variables (coded as continuous) with the genotype variables (coded as dummy variables) compared to null model with only main effects for dietary variables and genotypes.
c
Based on False Discovery Rate