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. 2011 Mar;162(5):1045–1059. doi: 10.1111/j.1476-5381.2010.01125.x

Table 2.

Cell cycle genes that are differentially regulated in pancreatic cancer cells after treatment with the respective IC50 of nemorosone for 24 h

Fold change
EntrezGene ID Gene symbol Description MIA-PaCa-2 AsPC-1 Capan-1
472 ATM Ataxia telangiectasia mutated 1.75 2.64 1.77
699 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homologue 1.87 −2.82 −3.12
890 CCNA2 Cyclin A2 −3.25 −2.51 −2.54
891 CCNB1 Cyclin B1 −1.28 −21.08 −3.40
9133 CCNB2 Cyclin B2 −1.66 −14.24 −6.87
595 CCND1 Cyclin D1 −1.84 −1.88 −1.66
894 CCND2 Cyclin D2 −1.23 −1.38 −1.01
983 CDC2 Cell division cycle 2, G1 to S and G2 to M 1.23 −7.32 −6.06
991 CDC20 Cell division cycle 20 homologue (S. cerevisiae) −1.78 1.20 1.16
994 CDC25B Cell division cycle 25 homologue B (S. pombe) −1.27 −1.03 −1.49
1019 CDK4 Cyclin-dependent kinase 4 −1.64 −2.52 −2.37
1022 CDK7 Cyclin-dependent kinase 7 2.67 1.54 2.03
1026 CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1) 11.35 54.27 21.58
1027 CDKN1B Cyclin-dependent kinase inhibitor 1B (p27, Kip1) −1.48 −3.74 −2.63
1032 CDKN2D Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) −1.02 −1.29 −1.40
8454 CUL1 Cullin 1 1.12 1.99 1.30
1869 E2F1 E2F transcription factor 1 −1.96 −2.00 −1.95
1647 GADD45A Growth arrest and DNA-damage-inducible, alpha 4.06 1.29 1.88
4085 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) −3.93 −8.06 −12.69
4171 MCM2 Minichromosome maintenance complex component 2 −3.85 −5.70 −4.53
4172 MCM3 Minichromosome maintenance complex component 3 1.63 1.74 1.94
4175 MCM6 Minichromosome maintenance complex component 6 −1.98 −4.69 −3.30
4176 MCM7 Minichromosome maintenance complex component 7 −1.84 −3.20 −3.77
5111 PCNA Proliferating cell nuclear antigen −5.50 −23.10 −15.83
5347 PLK1 Polo-like kinase 1 (Drosophila) −1.69 −13.68 −8.23
5591 PRKDC Protein kinase, DNA-activated, catalytic polypeptide 1.69 −1.18 −1.48
9232 PTTG1 Pituitary tumor-transforming 1 −1.35 −11.31 −7.29
5934 RBL2 Retinoblastoma-like 2 (p130) 3.01 3.80 3.75
2810 SFN Stratifin −1.11 3.30 3.21
6500 SKP1 S-phase kinase-associated protein 1 −1.06 −2.33 −2.96
6502 SKP2 S-phase kinase-associated protein 2 (p45) 2.33 2.63 2.30
7027 TFDP1 Transcription factor Dp-1 −1.12 −8.88 −3.71

A detailed list with all treatment conditions and P-values is provided in the supporting information.