Table 2.

Cell cycle genes that are differentially regulated in pancreatic cancer cells after treatment with the respective IC₅₀ of nemorosone for 24 h

			Fold change
EntrezGene ID	Gene symbol	Description	MIA-PaCa-2	AsPC-1	Capan-1
472	ATM	Ataxia telangiectasia mutated	1.75	2.64	1.77
699	BUB1	BUB1 budding uninhibited by benzimidazoles 1 homologue	1.87	−2.82	−3.12
890	CCNA2	Cyclin A2	−3.25	−2.51	−2.54
891	CCNB1	Cyclin B1	−1.28	−21.08	−3.40
9133	CCNB2	Cyclin B2	−1.66	−14.24	−6.87
595	CCND1	Cyclin D1	−1.84	−1.88	−1.66
894	CCND2	Cyclin D2	−1.23	−1.38	−1.01
983	CDC2	Cell division cycle 2, G1 to S and G2 to M	1.23	−7.32	−6.06
991	CDC20	Cell division cycle 20 homologue (S. cerevisiae)	−1.78	1.20	1.16
994	CDC25B	Cell division cycle 25 homologue B (S. pombe)	−1.27	−1.03	−1.49
1019	CDK4	Cyclin-dependent kinase 4	−1.64	−2.52	−2.37
1022	CDK7	Cyclin-dependent kinase 7	2.67	1.54	2.03
1026	CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.35	54.27	21.58
1027	CDKN1B	Cyclin-dependent kinase inhibitor 1B (p27, Kip1)	−1.48	−3.74	−2.63
1032	CDKN2D	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	−1.02	−1.29	−1.40
8454	CUL1	Cullin 1	1.12	1.99	1.30
1869	E2F1	E2F transcription factor 1	−1.96	−2.00	−1.95
1647	GADD45A	Growth arrest and DNA-damage-inducible, alpha	4.06	1.29	1.88
4085	MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	−3.93	−8.06	−12.69
4171	MCM2	Minichromosome maintenance complex component 2	−3.85	−5.70	−4.53
4172	MCM3	Minichromosome maintenance complex component 3	1.63	1.74	1.94
4175	MCM6	Minichromosome maintenance complex component 6	−1.98	−4.69	−3.30
4176	MCM7	Minichromosome maintenance complex component 7	−1.84	−3.20	−3.77
5111	PCNA	Proliferating cell nuclear antigen	−5.50	−23.10	−15.83
5347	PLK1	Polo-like kinase 1 (Drosophila)	−1.69	−13.68	−8.23
5591	PRKDC	Protein kinase, DNA-activated, catalytic polypeptide	1.69	−1.18	−1.48
9232	PTTG1	Pituitary tumor-transforming 1	−1.35	−11.31	−7.29
5934	RBL2	Retinoblastoma-like 2 (p130)	3.01	3.80	3.75
2810	SFN	Stratifin	−1.11	3.30	3.21
6500	SKP1	S-phase kinase-associated protein 1	−1.06	−2.33	−2.96
6502	SKP2	S-phase kinase-associated protein 2 (p45)	2.33	2.63	2.30
7027	TFDP1	Transcription factor Dp-1	−1.12	−8.88	−3.71

A detailed list with all treatment conditions and P-values is provided in the supporting information.