Table 1.

ED₅₀ values and 95% confidence limits for Δ⁹-tetrahydrocannabinol (Δ⁹-THC) alone and in combination with various doses (0.32–3.2 mg·kg⁻¹) of rimonabant in monkeys responding for food presentation (Food) and stimulus-shock termination (SST)

	ED50 in mg·kg−1 (95% confidence limits)	Potency ratio† (95% confidence limits)
Food
Δ9-THC alone	0.17 (0.055–0.54)
+0.32 Rimonabant	0.22 (0.097–0.48)	1.3 (0.4–4.0)
+1 Rimonabant	0.60 (0.19–1.9)	3.5 (1.0–13)
+3.2 Rimonabant	2.3* (0.60–8.8)	14 (3.6–50)
SST
Δ9-THC alone	0.058 (0.024–0.14)
+0.32 Rimonabant	0.13 (0.058–0.38)	2.2 (0.6–8.6)
+1 Rimonabant	0.39* (0.06–2.6)	6.7 (1.1–41)
+3.2 Rimonabant	0.79* (0.31–2.0)	14 (4.0–46)

^†Potency ratios and 95% confidence limits are equal to the ED₅₀ values of Δ⁹-THC in combination with a dose of rimonabant divided by the ED₅₀ value of Δ⁹-THC alone.

^*Significantly different from Δ⁹-THC alone.