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. 2011 Mar;162(5):1186–1201. doi: 10.1111/j.1476-5381.2010.01123.x

Figure 6.

Figure 6

Effect of glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) inhibition on expression of the adhesion molecules intercellular adhesion molecule 1 (ICAM-1) and P-selectin. Twenty-four hours after cerulein injection, immunohistochemical localization of ICAM-1 and P-selectin in pancreas of GITR+/+ mice showed a positive staining for both ICAM-1 (B) and P-selectin (F), when compared with sham-operated mice (A and E respectively). There was no detectable immunostaining for ICAM-1 and P-selectin in pancreas of cerulein-treated GITR−/− mice (C and G, respectively) and cerulein/Fc-GITR (6.25 µg/mouse of Fc-GITR, by mini-osmotic pump) co-treated GITR+/+ mice (D and H respectively). Photographs are representative of one out of three independent experiments (including five mice in each group). Panel I: myeloperoxidase activity in pancreatic samples of cerulein-treated GITR+/+ mice was significantly increased compared to sham-treated mice. Cerulein-treated GITR−/− mice and cerulein/Fc-GITR (6.25 µg·mouse−1 of Fc-GITR, by mini-osmotic pump) co-treated GITR+/+ mice showed a significantly decrease of MPO activity in pancreas (C). One representative experiment out of three is shown. Data are expressed as mean ± SE of 10 mice each group. *P < 0.01 versus sham; #P < 0.01 versus cerulein-treated GITR+/+ mice.