Table 3. Molecular genetic diversity indexes among populations (ΦST), within geographic groups (ΦSC) and among geographic groups (ΦCT) and correlation coefficients between genetic and geographic distances (r) in all populations taken together and when excluding TW, OCE and AME, at each HLA locus under study.
| All populations | ||||||
| Locus | n | ΦST (%) | r | N | ΦCT (%) | ΦSC (%) |
| A | 97 (92) | 8.16 *** | 0.184 *** | 11 | 3.5 *** | 5.07 *** |
| B | 90 (85) | 5.95 *** | 0.167 *** | 11 | 2.6 *** | 3.67 *** |
| Cw | 68 (63) | 6.61 *** | 0.226 *** | 10 | 3.89 *** | 3.11 *** |
| DRB1 | 106 (105) | 7.43 *** | 0.305 *** | 9 | 9.29 *** | 6.2 *** |
| DQA1 | 58 | 13.13 *** | 0.396 *** | 10 | 10.58 *** | 4.16 *** |
| DQB1 | 89 | 8.84 *** | 0.468 *** | 10 | 5.38 *** | 4.15 *** |
| DPB1 | 56 | 14.49 *** | 0.329 *** | 11 | 3.62 *** | 4.22 *** |
n: number of populations; N: number of geographic groups; ***: P<0.001.
In a few cases, because a precise geographic location was not available for some populations, the number of populations studied (n) was different for r calculations, as indicated within brackets. ΦST and r values for each different geographic group are given in File S3. OCE (Oceania) includes PAC and AUS; AME (the Americas) includes NAM and SAM.