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. 2011 Feb 1;6(2):e14643. doi: 10.1371/journal.pone.0014643

Table 4. Testing for the presence of significant conversion fragments within HLA genes (ordered according to their location on chromosome 6, from telomere to centromere) with the GENECONV program package.

Locus Number of sequences Number of nucleotide sites1 Number of polymorphic sites2 Number of significant conversion fragments (no correction) Number of significant conversion fragments (BLAST correction)3 Number of significant conversion fragments (Bonferroni correction)4
HLA-A 414 546 157 23444 5 0
HLA-Cw 231 546 112 2145 2 0
HLA-B 755 546 160 102890 611 0
HLA-DRB1 438 270 90 19917 15 0
HLA-DQA1 33 249 45 179 1 0
HLA-DQB1 70 270 37 164 0 0
HLA-DPB1 121 264 43 2252 99 0

Computations are done with 0% of missing data allowed at each nucleotide site, and using all sequences described in the IMGT official database (release 2.13).

1

Exons 2 and 3 for class I genes, exon 2 for class II genes.

2

This represents the number of nucleotide sites used by the program for detecting putative conversion fragments.

3,4

Number of fragments remaining significant after corrections for multiple tests. The BLAST correction is described as more powerful than Bonferroni's correction by the author of GENECONV.