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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Physiol Rev. 2011 Jan;91(1):221–264. doi: 10.1152/physrev.00052.2009

FIGURE 4. HA FRAGMENT.

FIGURE 4

Purified HA fragments but not HMW-HAinduced NF-KB DNA binding activity in MH-S cells. (A) Densitometric scanning demonstrating the molecular weights of HMW-HA (top), and purified HA fragments (bottom). (B) Electrophoretic mobility shift assay of nuclear extracts prepared from MH-S cell stimulated for 2 h with either serum-free media (unstim), HMW-HA, HA-fragment, or LPS. HA fragments induced NF-KB DNA binding activity. From Noble et al., J. Exp. Med. 183:2373–2378 (1996), with permission.