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. Author manuscript; available in PMC: 2011 Mar 9.
Published in final edited form as: Front Biosci. 2011 Jan 1;16:74–104. doi: 10.2741/3677

Figure 6.

Figure 6

Inhibition of neuronal activity or blockade of ionotropic glutamate receptors in the LPBel reverses shivering and non-shivering thermogenesis and metabolic and cardiac responses that are evoked by skin cooling. A, skin cooling-evoked changes in BAT SNA, TBAT, Exp. CO2 and HR before and after bilateral nanoinjections (green dashed lines) of the GABAA receptor agonist, muscimol, into the LPBel. The vertical scale bar for the BAT SNA trace represents 100 microvolts. B, skin cooling-evoked changes in nuchal EMG before and after bilateral nanoinjections (green dashed lines) of a mixture of the glutamate receptor antagonists, AP5 and CNQX, into the LPBel. The vertical scale bar for the EMG trace represents 400 microvolts. C, representative view of a nanoinjection site in the LPBel as identified with a cluster of fluorescent beads (arrow). Reproduced with permission from (27).