Table 1.
Lesions from female FVB/N mice transplanted with male MMTV-PyMT bone marrow cells.
| Mouse No. |
AGE AT DEATH* (Mos.) |
Gross Description | Glomerulo- Sclerosis |
Histologic Findings | Y+ |
|---|---|---|---|---|---|
| 1 | 14 | Breast mass (1.5cm) Splenomegaly |
+ | Squamous Cell Carcinoma Extramedullary Hematopoiesis Mammary Intraductal neoplasia |
No Yes No |
| 2 | 16 | Breast mass (2mm) Lung mass (3mm) Small spleen Firm lungs |
+++ | Atypical cystic mammary hyperplasia Lung Adenoma Splenic Atrophy. Chronic Pneumonia |
No No ND ND |
| 3 | 19 | Perirenal mass (3mm) | +++ | Perirenal Fibrosarcoma Chronic Pneumonia |
Yes |
| 4 | 19 | Breast masses, 0.7–1.2 cm Adrenal mass (4mm) Splenomegaly |
++ | Breast Adenocarcinoma Adrenal Medullary Tumor Cleaved Mixed Cell Lymphoma |
Yes No No |
| 5 | 19 | Adrenal mass (5mm) | +++ | Adrenal Medullary Tumor | No |
| 6 | 21 | Normal Periorbital mass (7mm) Lung (4mm) |
+++ | Breast Dilated ducts Periorbital Adenocarcinoma (Harderian Gland) Lung Adenocarcinoma |
No No No |
| 7 | 21 | Lung mass (3mm) | +++ | Lung Adenoma | No |
| 8 | 23 | Bilateral neck mass (7mm) | 0 | Salivary gland adenocarcinoma | No |
ND = not done.