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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Mol Microbiol. 2010 Sep 27;78(4):1038–1054. doi: 10.1111/j.1365-2958.2010.07389.x

Fig. 1.

Fig. 1

Deletion of acuM results in reduced virulence in G. mellonella and murine models of invasive aspergillosis. (A) Survival of G. mellonella larvae after injection with conidia of the indicated strains. Representative results of one of three experiments, each with 35 larvae per strain. (B) Survival of neutropenic mice with hematogenously disseminated aspergillosis. Mice were immunosuppressed with cyclophosphamide and cortisone acetate, inoculated intravenously with germlings of the indicated strain, and followed for survival. Results are the combined data from two experiments for a total of 13–19 mice per strain. (C) Survival of non-neutropenic mice with invasive pulmonary aspergillosis. Mice were immunosuppressed with cortisone acetate and then inoculated by placing them in an acrylic chamber filled with an aerosol of conidia from the indicated strains of A. fumigatus. Results are the combined data from two experiments for a total of 15–16 mice per strain. *P ≤ 0.005 compared to Af293 and the ΔacuM∷acuM complemented strains.