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. Author manuscript; available in PMC: 2011 Mar 9.
Published in final edited form as: J Clin Oncol. 2008 Jun 20;26(18):2959–2965. doi: 10.1200/JCO.2007.15.1928

Table 5.

CYP3A4 activity and docetaxel pharmacokinetics during cycles 1 and 2.

Parameter Cycle 1, mean (SD) Cycle 2, mean (SD) P-value
ERMBT C20min, %dose/min 0.044 (0.0082) 0.044 (0.0091) 0.8734
Cmax, μg/mL 4.83 (1.60) 4.86 (1.55) 0.9060
AUCinf, μg/mL*h 7.82 (3.01) 7.25 (2.12) 0.5561
CL, L/h 23.9 (12.1) 23.6 (7.43) 0.8822
t1/2,γ, h 86.2 (37.5) 65.8 (15.0) 0.0554
Vss, L 871 (433) 667 (189) 0.1513

Abbreviations: ERMBT, erythromycin breath test; C20min, flux of 14 CO2 at 20 min after administration of the ERMBT; Cmax, maximum plasma concentration; AUCinf, area under the concentration-time curve from time zero to infinity; CL, clearance; t1/2,γ, gamma half-life; Vss, volume of distribution at steady-state, SD, standard deviation.