Table 5.
Parameter | Cycle 1, mean (SD) | Cycle 2, mean (SD) | P-value |
---|---|---|---|
ERMBT C20min, %dose/min | 0.044 (0.0082) | 0.044 (0.0091) | 0.8734 |
Cmax, μg/mL | 4.83 (1.60) | 4.86 (1.55) | 0.9060 |
AUCinf, μg/mL*h | 7.82 (3.01) | 7.25 (2.12) | 0.5561 |
CL, L/h | 23.9 (12.1) | 23.6 (7.43) | 0.8822 |
t1/2,γ, h | 86.2 (37.5) | 65.8 (15.0) | 0.0554 |
Vss, L | 871 (433) | 667 (189) | 0.1513 |
Abbreviations: ERMBT, erythromycin breath test; C20min, flux of 14 CO2 at 20 min after administration of the ERMBT; Cmax, maximum plasma concentration; AUCinf, area under the concentration-time curve from time zero to infinity; CL, clearance; t1/2,γ, gamma half-life; Vss, volume of distribution at steady-state, SD, standard deviation.