Table 1.

Definitions and Stratifications

Drugdex Scoring Criteria

Efficacy: effective, evidence favors efficacy, evidence is inconclusive, ineffective

Strength of recommendation: class I (recommended), class IIa (recommended in most cases), class IIb (recommended in some cases), class III (not recommended)

Strength of evidence: grade A (good RCT evidence), grade B (less consistent RCT evidence), grade C (non-RCT forms of evidence)

Off-Label Stratification Definitions

Evidence-based off-label use: efficacy is effective or favors efficacy, evidence is A or B, and recommendation is I or IIa

Uncertain evidence base for off-label use: evidence A or B, and class IIb

Inadequate evidence for off-label use: efficacy is inconclusive or ineffective, evidence is C, or recommendation is III

Abbreviation: RCT, randomized clinical trial.