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Reduced pH-sensitivity in the Kir1.1 S172T mutation. Measurement of the pH-sensitivity of the S172T mutation in giant excised patches from Xenopus oocytes. The S172T mutation markedly reduces channel pH-sensitivity (IC50 = 5.8 ± 0.1) compared to wild-type Kir1.1 (IC50 = 6.5 ± 0.1).
