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The pH-sensitivity of activatory mutations identified in 30C chimera
| IC50 | |
| WT Kir1.1 | 6.5 ± 0.1 |
| G54C | 6.1 ± 0.1 |
| Y113C | 6.5 ± 0.1 |
| T129A | 6.6 ± 0.1 |
| V140M | N.D. |
| S172T | 5.8 ± 0.1 |
| R184S | 6.1 ± 0.1 |
| K186Q | 6.9 ± 0.1 |
| K187N | 6.3 ± 0.1 |
| T193M | 6.7 ± 0.2 |
| V199L | 6.3 ± 0.1 |
| S249I | N.D. |
All except the S249I mutation were located in the Kir1.1 section of the chimera.
