Table 2.
The top candidates identified by the GBA algorithm (genes with similar functional attributes are clustered together)
| Candidate Genes | Normal | Adenoma | Carcinoma | Inflammation | Condition Specificity | Colon tissue specificity | Secreted Proteins | Transcription Factors | Protein kinases | PTMs | DNA Methylation |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GUCA2B | 11.01 | 5.66 | 7.52 | 8.05 | ✓ | ✓ | ✓ | ✓ | |||
| MMP1 | 6.35 | 9.2 | 10.28 | 10.48 | ✓ | ✓ | ✓ | ||||
| PAPPA | 6.51 | 5.88 | 7.71 | 7.12 | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| PYY | 10.14 | 4.76 | 6.87 | 8.21 | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| REG1A | 5.71 | 10.87 | 10.8 | 12.17 | ✓ | ✓ | ✓ | ✓ | |||
| MEF2C | 8.66 | 7.36 | 8.43 | 9.04 | ✓ | ||||||
| SOX2 | 4.18 | 3.39 | 4.61 | 3.89 | ✓ | ✓ | ✓ | ||||
| SPIB | 9.11 | 6.15 | 6.76 | 8.26 | ✓ | ✓ | ✓ | ✓ | |||
| WWTR1 | 8.31 | 7.22 | 8.69 | 8.78 | ✓ | ✓ | ✓ | ||||
| ZIC2 | 2.22 | 4.8 | 3.53 | 2.55 | ✓ | ✓ | ✓ | ||||
| CDK8 | 8.62 | 8.75 | 8.96 | 8.29 | ✓ | ✓ | |||||
| EPHB3 | 8.58 | 9.97 | 8.63 | 8.12 | ✓ | ✓ | ✓ | ✓ | |||
| ROR2 | 5.16 | 4.4 | 5.47 | 5.56 | ✓ | ✓ | |||||
| NPR1 | 5.02 | 3.36 | 4.42 | 4.71 | ✓ | ✓ | ✓ | ||||
| TRIB3 | 6.93 | 8.76 | 9.01 | 7.84 | ✓ | ||||||
| TRPM6 | 10.54 | 6.27 | 8.04 | 7.08 | ✓ | ✓ | ✓ | ||||
| GCG | 10.42 | 6.24 | 7.69 | 9.55 | ✓ | ✓ | ✓ | ✓ | |||
| REG3A | 4.95 | 10.34 | 10.1 | 11.19 | ✓ | ✓ | ✓ | ✓ | |||
| SERPING1 | 8.9 | 8.11 | 9.28 | 10.21 | ✓ | ✓ | |||||
| SLC4A4 | 11.76 | 8.76 | 9.57 | 9.81 | ✓ | ✓ | ✓ | ||||