Table 1.
Genotype and allele distributions of the six SNPs in the MUC4 gene in Taiwanese endometriosis patients and controlsa
| SNPs | Genotype/allele | No. (%)of patients | HWE | No. (%)of controls | HWE | P value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| rs882605 | TT | 9 | (7.0) | 0.62 | 10 | (7.2) | 0.07 | 0.04 | 1.13 | (0.43 to 3.00) |
| TG | 54 | (42.2) | 40 | (28.8) | 1.97 | (1.17 to 3.32)b | ||||
| GG | 65 | (50.8) | 89 | (64.0) | 1.00 | Reference | ||||
| T | 72 | (28.1) | 60 | (21.6) | 0.08 | 1.42 | (0.96 to 2.11) | |||
| G | 184 | (71.9) | 218 | (78.4) | 1.00 | Reference | ||||
| rs1104760 | CC | 7 | (5.4) | 0.94 | 9 | (6.3) | 0.09 | 0.30 | 0.96 | (0.33 to 2.82) |
| CT | 47 | (36.2) | 39 | (27.5) | 1.49 | (0.89 to 2.51) | ||||
| TT | 76 | (58.5) | 94 | (66.2) | 1.00 | Reference | ||||
| C | 61 | (23.5) | 57 | (20.1) | 0.34 | 1.22 | (0.81 to 1.84) | |||
| T | 199 | (76.5) | 227 | (79.9) | 1.00 | Reference | ||||
| rs2246901 | GG | 8 | (6.0) | 0.96 | 10 | (7.1) | 0.15 | 0.56 | 0.91 | (0.33 to 2.53) |
| TG | 49 | (36.6) | 43 | (30.5) | 1.30 | (0.78 to 2.17) | ||||
| TT | 77 | (57.5) | 88 | (62.4) | 1.00 | reference | ||||
| G | 65 | (24.3) | 63 | (22.3) | 0.60 | 1.11 | (0.75 to 1.65) | |||
| T | 203 | (75.7) | 219 | (77.7) | 1.00 | Reference | ||||
| rs2258447 | AA | 9 | (6.4) | 0.37 | 10 | (7.0) | 0.07 | 0.70 | 1.02 | (0.38 to 2.77) |
| AG | 44 | (32.1) | 40 | (28.2) | 1.25 | (0.74 to 2.11) | ||||
| GG | 81 | (61.4) | 92 | (64.8) | 1.00 | Reference | ||||
| A | 62 | (22.5) | 60 | (21.1) | 0.57 | 1.12 | (0.75 to 1.68) | |||
| G | 206 | (77.5) | 224 | (78.9) | 1.00 | Reference | ||||
| rs2291652 | CC | 11 | (8.7) | 0.92 | 11 | (8.4) | 0.26 | 0.52 | 1.17 | (0.46 to 2.96) |
| CT | 52 | (40.9) | 45 | (34.4) | 1.35 | (0.81 to 2.28) | ||||
| TT | 64 | (50.4) | 75 | (57.3) | 1.00 | Reference | ||||
| C | 74 | (29.1) | 67 | (25.6) | 0.36 | 1.20 | (0.81 to 1.76) | |||
| T | 180 | (70.9) | 195 | (74.4) | 1.00 | Reference | ||||
| rs2688513 | CC | 8 | (6.0) | 0.62 | 10 | (7.0) | 0.09 | 0.66 | 0.91 | (0.33 to 2.53) |
| TC | 45 | (33.8) | 41 | (28.9) | 1.25 | (0.74 to 2.10) | ||||
| TT | 80 | (60.2) | 91 | (64.1) | 1.00 | Reference | ||||
| C | 61 | (22.9) | 61 | (21.5) | 0.68 | 1.09 | (0.73 to 1.63) | |||
| T | 205 | (77.1) | 223 | (78.5) | 1.00 | Reference | ||||
aMUC4, mucin 4 gene; SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval; HWE, P values of deviation from the Hardy-Weinberg equilibrium constant. Allelic frequencies were determined by χ2 test using 2 × 2 contingency tables. Genotype frequencies were determined by χ2 test using 2 × 3 contingency tables. bP < 0.05 was considered statistically significant.