Table 4.
Genotype and allele distributions of the six SNPs in the MUC4 gene in endometriosis patients with different reproductive abilitya
| SNP | Genotype/allele | No. (%) infertility | No. (%) noninfertility | P value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|
| rs882605 | TT | 0 | (0.0) | 8 | (8.7) | 0.07 | - | - |
| TG | 5 | (26.3) | 42 | (45.7) | 0.36 | (0.12 to 1.08) | ||
| GG | 14 | (73.7) | 42 | (45.7) | 1.00 | Reference | ||
| T | 5 | (13.2) | 58 | (31.5) | 0.03b | 0.33 | (0.12 to 0.89) | |
| G | 33 | (86.8) | 126 | (68.5) | 1.00 | Reference | ||
| rs1104760 | CC | 0 | (0.0) | 6 | (6.3) | 0.41 | - | - |
| CT | 4 | (25.0) | 37 | (38.5) | 0.48 | (0.14 to 1.60) | ||
| TT | 12 | (75.0) | 53 | (55.2) | 1.00 | Reference | ||
| C | 4 | (12.5) | 49 | (25.5) | 0.12 | 0.42 | (0.14 to 1.25) | |
| T | 28 | (87.5) | 143 | (74.5) | 1.00 | Reference | ||
| rs2688513 | CC | 0 | (0.0) | 7 | (7.4) | 0.32 | - | - |
| TC | 5 | (25.0) | 34 | (36.2) | 0.52 | (0.17 to 1.56) | ||
| TT | 15 | (75.0) | 53 | (56.4) | 1.00 | Reference | ||
| C | 5 | (12.5) | 48 | (25.5) | 0.09 | 0.42 | (0.15 to 1.12) | |
| T | 35 | (87.5) | 140 | (74.5) | 1.00 | Reference | ||
| rs2246901 | GG | 0 | (0.0) | 7 | (7.4) | 0.25 | - | - |
| TG | 5 | (25.0) | 37 | (38.9) | 0.46 | (0.15 to 1.38) | ||
| TT | 15 | (75.0) | 51 | (53.7) | 1.00 | Reference | ||
| G | 5 | (12.5) | 51 | (26.8) | 0.06 | 0.39 | (0.14 to 1.05) | |
| T | 35 | (87.5) | 139 | (73.2) | 1.00 | Reference | ||
| rs2258447 | AA | 1 | (5.0) | 7 | (7.3) | 0.41 | 0.53 | (0.05 to 5.53) |
| AG | 4 | (20.0) | 33 | (34.4) | 0.45 | (0.14 to 1.48) | ||
| GG | 15 | (75.0) | 56 | (58.3) | 1.00 | Reference | ||
| A | 6 | (15.0) | 47 | (24.5) | 0.22 | 0.54 | (0.22 to 1.38) | |
| G | 34 | (85.0) | 145 | (75.5) | 1.00 | Reference | ||
| rs2291652 | CC | 0 | (0.0) | 7 | (7.8) | 0.29 | - | - |
| CT | 7 | (35.0) | 40 | (44.4) | 0.58 | (0.21 to 1.60) | ||
| TT | 13 | (65.0) | 43 | (47.8) | 1.00 | Reference | ||
| C | 7 | (17.5) | 54 | (30.0) | 0.12 | 0.49 | (0.21 to 1.19) | |
| T | 33 | (82.5) | 126 | (70.0) | 1.00 | Reference | ||
aSNP, single-nucleotide polymorphism; MUC4, mucin 4 gene; OR, odds ratio; 95% CI, 95% confidence interval. Allelic frequencies were determined by Fisher's exact test using 2 × 2 contingency tables. Genotype frequencies were determined by Fisher's exact test using 2 × 3 contingency tables. bP < 0.05 was considered statistically significant.