Figure 1.

Modeling TREK-1 channel. (A) Schematic illustrating our approach to modeling TREK-1 channels: two KCSA subunits were used to model one TREK subunit; linker and C-terminal regions were modeled ab initio; helical segments are represented by cylinders. (B) Target-template sequence alignment used for modeling; identical residues are highlighted magenta, selectivity filter is highlighted orange; M1P1 loop was not included in the models; helical segments are underlined using the same color scheme as in (A). (C) Bottom view and (D) side view of structural models for the closed (left part), low-conductive (central part) and open (right part) conformation, in ribbon representation; helical segments are labeled and colored using the same color scheme as in (A and B).