Figure 2.

Association of estimated GFR with cognitive impairment in unadjusted and adjusted models among 3591 CRIC participants. The bars indicate 95% confidence intervals. Referent category is eGFR 45 to 59 ml/min per 1.73 m². An asterisk indicates P < 0.05. P for linear trend across eGFR strata = <0.0001, 0.059, 0.063, and 0.052 in the unadjusted, demographics adjusted, traditional vascular risk factor adjusted, and fully adjusted models, respectively. CVD, cardiovascular disease; CV, cardiovascular. ^†Model adjusted for eGFR, age, sex, race, ethnicity, education, stroke, and CRIC clinical site. ^‡Model adjusted for eGFR, age, sex, race, ethnicity, education, stroke, diabetes, hypertension, smoking, history of elevated cholesterol, coronary heart disease, peripheral arterial disease, and CRIC clinical site. ^††Model adjusted for eGFR, age, sex, race, ethnicity, education, stroke, hemoglobin, and CRIC clinical site.